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All about COVID19 - An initiative from WhiteCoats that brings together updates from top curated resources exclusively for healthcare professionals

Researchers in the US report a new orally used compound known as “PTC299” which is a potent inhibitor of dihydroorotate dehydrogenase (DHODH). SARS-COV-2 is a single-stranded RNA virus that enters the human host cell via its attachment to the ACE2 receptor, a membrane protein in the renin-angiotensin pathway. The virus binds itself to the S1 subunit of the enzyme and ...

Biomarkers are the biological markers that are evaluated in the clinical scenario to act as an indicator of certain biological, pathogenic, or pharmacological processes. This particular knowledge was inculcated in a retrospective cohort study, to identify the association that might reside between biomarkers observed in COVID-19 exposed individuals with their clinical outcomes. To identify the possible association, laboratory tests were ...

It is known after observation and investigation that the severe cases of COVID-19 patients can lead to obstruction of blood vessels in the heart, lungs, and kidneys. Activated immune cells and blood platelets play a vital role in these pathologies. The virus basically affects the respiratory tract and in some worse cases, it results in lung failure. This leads to ...

The emergence of SARS-CoV-2 and its global spread since late 2019 still has many gates that need to be open. However, continuous scientific research and experimentation have always provided researchers with something that become the basis of another deeper research for combating COVID- 19. One such is, the marked T cell reactivity, observed in the geographically diverse cohort study, against ...

The race for developing a vaccine is on and the requirement exceeds day by day. It might take more time than expected but a vaccine is surely on its way. Regeneron pharmaceuticals state that its COVID-19 antibody-drug cocktail is working wonders in animals i.e. hamsters and monkeys. The cocktail of two monoclonal antibodies which is known as the REGN-COV-2 could ...

In order to understand the immunity against SARS-CoV-2 and the potential virus, the amount of neutralizing antibodies in the blood of the recovered patients has to be determined. A traditional test takes two to three days and must be carried out and must be carried out in the lab with infectious coronaviruses. A Swiss-German research team found a way to ...

Observations suggest that the pandemic causing virus shows at least 6 different strains. Even with the mutations, the virus is showing little variability which is a plus point for the researchers working on the vaccine.  These results were derived from the most extensive study ever carried out on SARS-CoV-2 sequencing. Scientists at the University of Bologna drew from the analysis ...

A recent study published supports the use of tetracycline as an immunomodulatory drug for COVID-19. These drugs have an anti-inflammatory effect and a broad-spectrum antibacterial activity. These drugs have been very useful in treating HIV and malaria. Their ability to suppress the proliferation of T cells and decrease the production of inflammation-signalling molecules is something that helps in the process. ...

Different approaches have been put into action to come up with a vaccine for the recent virus that has caused havoc. Hence, scientists are looking for passive protection that can help protect against the virus and can be useful for temporary purposes. In the process, scientists have come up with the discovery of an antigen to elicit neutralizing antibody responses. ...

The worldwide pharmaceutical industry is on a hunt for a vaccine for COVID-19 but tests for better effectiveness against the virus are also in the process. In a recent study, it was seen that extract from edible seaweed significantly performed better than remdesivir, the current standard antiviral used as a vaccine. Heparin which is a frequently used blood thinner and ...