fbpx
All about COVID19 - An initiative from WhiteCoats that brings together updates from top curated resources exclusively for healthcare professionals

Results of the phase 3 PRINCIPLE clinical trial published on a preprint server revealed a 3-day faster recovery of COVID-19 symptoms in people at high risk for severe side effects administered a budesonide inhaler. There was also a 2.1% reduction in hospitalization and death. Many other randomized trials have already demonstrated the benefits of systemic corticosteroids for the treatment of ...

A new study published on a pre-print server has described a new subunit nanovaccine that appears to have robust immunogenicity and neutralizing activity. The researchers drew on their earlier experience of polymersomes (PS), which are self-assembled bodies formed from the block copolymer poly(ethylene glycol)-bl-poly(propylene sulfide) (PEG-PPS). These were proved to effectively deliver antigen and adjuvant to the endosomes of dendritic ...

Researchers from the USA conducted a large-scale study to evaluate the efficacy of neutralizing monoclonal antibodies (MAbs). The study findings published on a pre-print server state that timing is a crucial factor in determining the efficacy of MAbs against COVID-19. A total of 2,818 symptomatic COVID-19 patients (average age: 67 years) who received MAB therapy were analyzed. Hypertension and obesity ...

Mathematical modeling of the effects of vaccine efficacy and the speed of vaccination show that a lower efficacy vaccine may curb disease transmission similar to that of a higher efficacy vaccine if the speed of immunization is high. A new study published on a preprint server analyzed vaccine efficacy and speed of vaccine distribution to understand how these affect controlling ...

Researchers worldwide are conducting extensive research to understand the nature of the virus. They have found a strong correlation between the ABO blood group and SARS-CoV-2 regarding its morbidity and mortality. New research from India published on a preprint server has associated blood group ABO and asymptomatic COVID-19. This study used random serosurveillance and blood group testing of street vendors ...

A study published on a preprint server describes the kinetics of antibody response to the earliest approved vaccines against COVID-19, which were developed on an mRNA platform. Humoral responses occur in the form of multiple antibody subsets, of which both IgG and IgA are key to neutralization of the virus, but have different parts to play in the immune response, ...

A study published on a pre-print server conducted by researchers at Sinopharm Wuhan Plasma-derived Biotherapies Co., Ltd and Wuhan Institute of Biological Products Co. Ltd, showed a positive rate of IgG antibody against the receptor-binding domain of the spike protein (RBD-IgG) to SARS-CoV-2 in COVID-19 convalescent plasma donors exceeded 70 percent for 12 months after infection. To arrive at this ...

A new study published on a pre-print server found that changes to the lung microbiome during SARS-CoV-2 infection influence COVID-19 disease severity. Researchers from the University of Pennsylvania Perelman School of Medicine have suggested a wide diversity in the microbiome is associated with less severe illness and the need for hospitalization. The researchers collected oropharyngeal or nasopharyngeal swabs from 83 ...

A study published on a preprint server has reported the high neutralizing efficacy of a polyclonal swine antibody against SARS-CoV-2. Polyclonal antibodies which recognize multiple epitopes on the spike protein have been explored as a therapeutic option. The current study conducted by the company Xenothera produced glycohumanized polyclonal antibodies. The current study examines a glycohumanized swine polyclonal antibody, called XAV-19, ...